The following article discusses the top healthcare content marketing agencies of 2025. Our research team compiled a total sample size of ~60 content marketing agencies, which we then rank according according to a proprietary algorithm consisting of:
- Year Established: The founding year of the agency, suggesting its ability to sustain a profitable business model and satisfy client needs over time.
- Founder Led: Whether or not the agency founder still works with the agency in either a C-suite or consulting position, suggesting whether or not the original vision of the agency remains intact.
- Leadership Experience Score: A qualitative 1-5 breakdown of the agency’s C-suite and upper management, based on prior experience in content marketing and/or healthcare, respectively.
- Average Review Score: A quantitative 1-5 score reflecting the average customer reviews from 3rd party sites online. Scores may experience a 1.5 point variation to reflect reviews of apparent healthcare clients.
- Median Employee Tenure: The average length of time employees stay with the agency expressed in years, suggesting the positivity of the overall work environment and, by extension, customer experience.
- Notable Healthcare Clients: The top three most recognizable healthcare clients listed on the agency’s website. In the event that healthcare clients are not listed, related fields like medtech can be used.
The table below consists of our top 8 scoring healthcare content marketing agencies, reflecting the total number of agencies scoring above an 80% in our algorithm. We have also provided a brief summary of each agency’s specialty within marketing.
The Top Healthcare Content Marketing Agencies of 2025
Rank | Company | Established | Founder Led | Leadership Experience | Average Review Score | Median Employee Tenure | Notable Healthcare Clients | Healthcare Content Marketing Specialty |
1 | First Page Sage | 2009 | Yes | 4.8 | 4.9 | 4.3 Years | Evexias, Dignity Health, GoHealth Urgent Care, | Creating healthcare thought leadership content for lead generation and branding |
2 | Real Chemistry | 2001 | Yes | 4.2 | 4.3 | 2.9 years | AstraZeneca, Johnson & Johnson | AI-driven advertising for life science companies |
3 | Epsilon | 1969 | No | 4.4 | 4.8 | 4.6 years | Visionworks, Walgreens | Full-service enterprise content marketing |
4 | FEED. The Agency | 2010 | Yes | 4.6 | 4.6 | No data | The Smile Center, Brain & Spine Surgeons of New York | Branding, reputation management, and video marketing |
5 | Cardinal Digital Marketing | 2009 | Yes | 4.1 | 4.5 | 1.8 years | North American Dental Group, Upperline Health, Greater Good Health | Webinar marketing for medtech companies |
6 | Amsive | 1995 | Yes | 4.0 | 4.3 | 3.0 years | Emergient, Vermont Blue Advantage | Branding, conversion optimization, and content marketing |
7 | No Good | 2016 | Yes | 4.5 | 4.0 | 1.8 years | Providence, Spring Health, Oura | Combining content marketing with PPC & social media advertising |
8 | Merkle | 1971 | No | 4.3 | 4.7 | 3.1 years | Novo Nordisk, City of Hope, University of Kansas Health System | Branding & web design services for healthcare companies |
The following sections detail each of the content marketing agencies listed in the table above, providing a more in-depth analysis of how they work, what they offer, and who they might be best for.
First Page Sage

First Page Sage is the leading healthcare content marketing agency in the US, and they specialize in creating thought leadership content to establish their clients leaders in the healthcare industry. They pair their content with SEO services to help bring in organic traffic, and can handle all aspects of healthcare content creation. This makes them an ideal match for businesses whose internal experts don’t have the time or resources to create content on their own.
First Page Sage has worked with several notable clients in the industry, ranging from healthcare providers like Dignity Health to medical device manufacturers like Intuity Medical. The quality of work delivered in these contracts is exceptionally high, as suggested by their customer review score as well as the relatively short tenure of the company compared to others on this list.
- Established: 2009
- Founder Led: Yes
- Leadership Experience: 4.8
- Average Review Score: 4.9
- Median Employee Tenure: 4.3 Years
- Notable Healthcare Clients:
- Content Marketing Specialty: B2B thought leadership content for healthcare innovators
- Contact: First Page Sage Website
Summary of Online Reviews |
Healthcare companies report that First Page Sage provides “expert medical writing services,” and form “real relationships” with clients, becoming “like an extension of [clients’] internal marketing team“. |
Real Chemistry

Real Chemistry specializes in AI-driven marketing based on an advanced analytics and insights program that identifies gaps in client’s websites and develops tailored strategies for their in-house teams to handle. Their content department specializes in “integrated communications,” which appears to emphasize content marketing through storytelling, making them a good match for healthcare companies that want to develop a more personalized connection with their clients.
Real Chemistry has worked with several recognizable companies within the healthcare sphere and their average customer scores suggest consistent quality in their work. Their leadership appears to be primarily from a marketing background, but our research does note limited healthcare experience, making them well-suited to handle the needs of healthcare clients.
- Established: 2001
- Founder Led: Yes
- Leadership Experience: 4.2
- Average Review Score: 4.3
- Median Employee Tenure: 2.9 years
- Notable Healthcare Clients: AstraZeneca, Johnson & Johnson
- Content Marketing Specialty: AI-driven advertising for life science companies
- Contact: Real Chemistry Website
Summary of Online Reviews |
Real Chemistry “worked with [clients] to meet [their] goals,” providing them with “teams of experts” that “introduce new ideas” while “understand[ing] the needs of the industry.” |
Epsilon

Epsilon is a healthcare content marketing agency that provides content marketing as one of several services, including branding, webdev, and social media. As such, their teams take a holistic approach to content marketing, providing content designed to work within a comprehensive framework. For healthcare companies looking to experiment with new marketing channels or seek new audiences, Epsilon’s omnichannel strategy makes an ideal menu of services.
Epsilon has the longest tenure of any healthcare content marketing agency on this list, reflected by a high leadership experience score. They appear to have relatively little experience with healthcare companies, albeit with a few exceptionally recognizable clients, but the breadth of their team’s experience makes them well-suited to the needs of various healthcare companies.
- Established: 1969
- Founder Led: No
- Leadership Experience: 4.4
- Average Review Score: 3.8
- Median Employee Tenure: 4.6 years
- Notable Healthcare Clients: Visionworks, Walgreens
- Content Marketing Specialty: Full-service enterprise content marketing
- Contact: Epsilon Website
Summary of Online Reviews |
Epsilon provides “excellent customer service by providing OUTCOME-based marketing” with a “nice report highlighting” system to keep clients updated on campaigns. Some reviews suggest that their approach is “not very adaptable.” |
FEED The Agency

FEED The Agency provides branding and PR services for healthcare companies. In, their teams provide video marketing services to create high-engagement videos that help healthcare companies educate and build trust with their audience. This makes their teams ideal for healthcare companies who are looking to establish their unique niche within the industry, repair their image, or roll out new products and services.
FEED The Agency has worked with several recognizable healthcare companies and has exceptional customer review and leadership experience scores. What’s even more impressive is that they have accomplished this in a relatively short period of time since their founding year, which suggests a high degree of competence found in their teams.
- Established: 2010
- Founder Led: Yes
- Leadership Experience: 4.6
- Average Review Score: 4.6
- Median Employee Tenure: No data
- Notable Healthcare Clients: The Smile Center, Brain & Spine Surgeons of New York
- Content Marketing Specialty: Branding, reputation management, and video marketing
- Contact: FEED. The Agency Website
Summary of Online Reviews |
Feed The Agency provides clients with options that “sell at scale,” allowing even smaller companies to create “emotive yet conversion-focused ideas” that “shift market behaviors.” |
Cardinal Digital Marketing

Cardinal Digital Marketing provides a niche marketing service for healthcare companies, specializing in webinar marketing. While they do provide several additional services such as PPC and social media, their specialty in webinar marketing makes them a good fit for healthcare companies who are seeking to warm up their marketing pipeline with interested leads and who already have a charismatic expert available to host.
Cardinal Digital Marketing has a solid history of working with recognizable healthcare brands, and a customer review score that suggests quality work throughout that time. Their C-suite appears to come primarily from a marketing background, however their teams appear to be well-informed enough on the healthcare industry to make them capable of meeting client needs.
- Established: 2009
- Founder Led: Yes
- Leadership Experience: 4.1
- Average Review Score: 4.5
- Median Employee Tenure: 1.8 years
- Notable Healthcare Clients: North American Dental Group, Upperline Health, Greater Good Health
- Content Marketing Specialty: Webinar marketing for medtech companies
- Contact: Cardinal Digital Marketing Website
Summary of Online Reviews |
Cardinal Digital Marketing does a “phenomenal job in driving results” for clients, providing “top marketing experts in their fields.” Their approach is “transparent, data-driven, and always evolving to improve.” |
Amsive

Amsive is a healthcare content marketing agency specializing in branding services, including the production of ad copy, logo design, and digital marketing strategy. They also provide direct mail and email marketing services to help healthcare companies nurture existing leads towards an eventual conversion. This suite of services makes them a good match for healthcare companies seeking to nail down their textual and visual language within the healthcare sphere.
Amsive has limited experience working with healthcare brands directly. Despite this and their three decades experience in content marketing, they have a solid customer review score that suggests an ability to handle customer needs as well as leadership with a solid level of experience in content marketing.
- Established: 1995
- Founder Led: Yes
- Leadership Experience: 4.0
- Average Review Score: 4.3
- Median Employee Tenure: 3.0 years
- Notable Healthcare Clients: Emergient, Vermont Blue Advantage
- Content Marketing Specialty: Branding, conversion optimization, and content marketing
- Contact: Amsive Website
Summary of Online Reviews |
Amsive “puts [clients] front and center,” possessing a “lot of energy and enthusiasm for [the client’s] project.” Their teams “actively collaborate at all stages of the process,” allowing for “more qualified traffic to the website.” |
No Good

No Good is a healthcare content marketing agency specializing in PPC and social media marketing, providing essential top-of-funnel marketing content to draw in the target audience. While their experience in paid social lends itself to the needs of B2B healthcare companies seeking to roll out new products or test new keyworks, their experience in social media marketing makes them an ideal choice for B2C healthcare companies looking to actively engage with retail customers.
No Good has worked with several healthcare clients in a relatively short tenure (the shortest on this list, in fact). Their leadership has experience in both content marketing as well as in the healthcare industry, making them well-tuned into the needs of various healthcare clients.
- Established: 2016
- Founder Led: Yes
- Leadership Experience: 4.5
- Average Review Score: 4.0
- Median Employee Tenure: 1.8 years
- Notable Healthcare Clients: Providence, Spring Health, Oura
- Content Marketing Specialty: Combining content marketing with PPC & social media advertising
- Contact: No Good Website
Summary of Online Reviews |
No Good provides “experienced and creative teams” that help clients “scale [their] business quickly.” A few reviews suggest “poor customer response” however, the vast majority describe them as “the best growth marketing agency” available. |
Merkle

Merkle specializes in healthcare content marketing through branding services, helping healthcare companies identify gaps within the healthcare industry to fill. From there, their teams help clients develop a unique tone and style for their written work that separates them from their competitors while building trust with their audience. This, as well as their webdev services, makes them an ideal match for healthcare companies seeking to give their website a digital face lift.
Merkle has worked with several notable clients within the healthcare space to great success, boasting an exceptionally high customer review score. Their leadership and upper management has some experience in content marketing and limited healthcare experience, making them knowledgeable about concerns within the healthcare industry.
- Established: 1971
- Founder Led: No
- Leadership Experience: 4.3
- Average Review Score: 4.7
- Median Employee Tenure: 3.1 years
- Notable Healthcare Clients: Novo Nordisk, City of Hope, University of Kansas Health System
- Content Marketing Specialty: Branding & web design services for healthcare companies
- Contact: Merkle Website
Summary of Online Reviews |
Merkle’s teams provide a “wide range of experiences” that “redefine your B2B marketing” approach. Some customers report that their services are “a little more higher priced” than some competitors, but their solutions are “very useful in relation to the customer experience.” |